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dr' 9

(1",1"') \7' . M (1"')]

(6.2.31)

The fields are expressed entirely in terms of magnetic current or in terms of magnetic current and magnetic charge. When both electric and magnetic sources are present, Eqs. (6.2.16)(6.2.15) and (6.2.30)-(6.2.31) are combined to give E(r) = -

5

dr' \79

Clinical therapeutics, one of the most prominent areas in the biotechnol ogy space, involves a variety of applications, from diagnosing and treating diseases, cloning, and life extension, to developing tissues and replacement organs for transplant surgery. Gene therapy, illustrated in Figure A.2, is a method of treating genetic diseases by replacing, manipulating, or supple menting nonfunctional or misfunctioning genes with healthy genes, typi cally through the use of a harmless virus. In this example, a patient suffering from a genetic disease that affects the lungs, such as cystic brosis, undergoes gene therapy by inhaling a mist of harmless viruses that carry therapeutic genes. The viruses create a thera peutic infection in the patient s lung tissue, releasing the therapeutic gene into individual cells in the patient s lung. Once in a lung cell, the therapeu tic gene is incorporated into one of the cell s chromosomes. As a result, the cell is able to synthesize a fully functioning protein that the patient s defec tive gene is incapable of producing. In some cases, such as cystic brosis, the lung cells produce a protein, but the protein is defective. The challenges facing companies developing gene therapies include high cost, the need for frequent, repeat treatment, and how to control the unintentional spread of the therapeutic gene to the reproductive organs,

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(1",1"')

(1"')

H (r) =

Some restrictions and rules apply when you use accessibility on the accessors:

dr'9

\7 \7

dr' 9

(1",1"') \7' . ] (1"')] (6.2.32)

dr' 9

The accessibility on the Property statement must be less restrictive than the accessibility on the accessor For example, you cannot define the Property statement to be private and then make the getter public You can add accessibility to the getter or setter, but not both If the getter needs to be friend and the setter needs to be private, for example, make the Property statement friend (the least restrictive), and make the setter private If you use the ReadOnly or WriteOnly keywords, you cannot add accessibility on the accessor

which could result in the gene being transferred to the patient s offspring. Although the latter may be of therapeutic value, there are moral, political, and legal implications regarding permanently altering a patient s progeny.

(1",1"') M (7") + (1",1"')

dr' 9

(1",1"')

(1"') ]

De ne accessibility appropriately to ensure that your properties are accessed only as they should be Most properties are public, but for some properties, such as IDs, de ne private setters to allow reading but not setting of the property

(6.2.33)

(1"')

and f.L2,

(6.2.34) (6.2.35) (6.2.36) (6.2.37)

Development of new and improved drugs is the motivation behind the pharmaceutical industry s vast investment in biotechnology. This invest ment is directed at more ef cient, more cost-effective development of drugs, drugs that produce fewer side effects and deliver greater ef cacy. There are several major areas of drug development research and develop ment. These range from taking the guess work out of drug to development (rational drug discovery) to creating patient-speci c designer or pharma cogenomic drugs, as illustrated in Figure A.3. Figure A.3 outlines the major steps in the designer drug process. Ini tially, a patient provides the laboratory with a DNA sample, which can

For the Purchase Tracker sample application: Open the Product class in the Code Editor Add a ProductID property with a private setter, as defined in this section Add code to declare a backing variable, and get and set its value in the property Add documentation for the ProductID property using XML comments This new property is used later in this chapter

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